abstract：BACKGROUND:Trinitrobenzenesulfonic acid (TNBS)-induced colitis is one of the most widely used experimental colitis models. However, there is no standard procedure for inducing colitis by TNBS because it is difficult to achieve a uniform distribution of colitis. We have developed a modified method of murine TNBS-induced...

journal_title：Digestive diseases and sciences

authors： Terai T,Osawa S,Tani S,Oishi S,Arai Y,Yamada T,Sugimoto M,Furuta T,Kanaoka S,Miyajima H,Sugimoto K

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:No study has evaluated current scoring systems for their accuracy in predicting short and long-term outcome of alcoholic hepatitis in a US population. METHODS:We reviewed electronic records for patients with alcoholic liver disease (ALD) admitted to Parkland Memorial Hospital between January 2002 and August...

journal_title：Digestive diseases and sciences

authors： Cuthbert JA,Arslanlar S,Yepuri J,Montrose M,Ahn CW,Shah JP

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND AIM:Second harmonic generation (SHG) is a novel imaging technology that could provide optical biopsy during endoscopy with advantages over current technology. SHG has the unique ability to evaluate the amount of extracellular matrix collagen protein and its alignment. METHODS:Hematoxylin- and eosin-stai...

journal_title：Digestive diseases and sciences

authors： Birk JW,Tadros M,Moezardalan K,Nadyarnykh O,Forouhar F,Anderson J,Campagnola P

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND AIM:The purpose of this study was to examine the association between celiac disease (CD) and prior respiratory syncytial virus (RSV) infection or any viral bronchiolitis. METHODS:This was a retrospective case-control study. During 2006-2008 small intestinal biopsy data were collected from Sweden's 28 pa...

journal_title：Digestive diseases and sciences

authors： Tjernberg AR,Ludvigsson JF

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The proliferation of cholangiocarcinoma cells is suppressed in cell culture by nonsteroidal antiinflammatory drugs (NSAIDs) through the inhibition of cyclo-oxygenase-2 enzyme and also by statins which decrease the production of mediators of the cell cycle. AIMS:To investigate whether there is an inverse ass...

journal_title：Digestive diseases and sciences

authors： Burr NE,Talboys RJ,Savva S,Clark A,Phillips M,Metcalfe M,Dennison A,Robinson R,Lewis MP,Rhodes M,Rushbrook S,Hart AR

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Ileocolic anastomosis is an essential step in the treatment to restore continuity of the gastrointestinal tract following ileocolic resection in patients with Crohn's disease (CD). However, the association between anastomotic type and surgical outcome is controversial. AIMS:The aim of this meta-analysis is ...

journal_title：Digestive diseases and sciences

authors： He X,Chen Z,Huang J,Lian L,Rouniyar S,Wu X,Lan P

更新日期：2014-07-01 00:00:00

abstract：BACKGROUNDS AND AIMS:We studied the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) as a possible therapy for non-steroidal anti-inflammatory drug (NSAID)-induced intestinal ulcers. Luminal nutrients release endogenous GLP-2 from enteroendocrine L cells. Since GLP-2 is degraded by dipeptidyl peptidase IV (DPPI...

journal_title：Digestive diseases and sciences

authors： Inoue T,Higashiyama M,Kaji I,Rudenkyy S,Higuchi K,Guth PH,Engel E,Kaunitz JD,Akiba Y

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) may reduce the risk of esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus. PPIs are prescribed for virtually all patients with Barrett's esophagus, irrespective of the presence of reflux symptoms, and represent a de facto chemopreventive agent in this populatio...

journal_title：Digestive diseases and sciences

authors： Sharaiha RZ,Freedberg DE,Abrams JA,Wang YC

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The antibiotic rifaximin is used to treat non-constipated irritable bowel syndrome (IBS). Methane production is associated with constipation and its severity in constipation-predominant IBS (C-IBS). A previous retrospective study suggested that rifaximin and neomycin was superior to neomycin alone in improvi...

journal_title：Digestive diseases and sciences

authors： Pimentel M,Chang C,Chua KS,Mirocha J,DiBaise J,Rao S,Amichai M

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Human hepatocellular carcinoma (HCC) is one of the most common fatal cancers and an important health problem worldwide, but its mechanism is still unclear. Microtubule (MT) kinesin motor proteins orchestrate a variety of cellular processes (e.g. mitosis, motility and organelle transportation) and have been i...

journal_title：Digestive diseases and sciences

authors： Huang X,Liu F,Zhu C,Cai J,Wang H,Wang X,He S,Liu C,Yao L,Ding Z,Zhang Y,Zhang T

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The early diagnosis of pancreas allograft dysfunction is crucial for the management and long-term survival of transplanted pancreases. We investigated whether intercellular adhesion molecular-1 (ICAM-1), Fas, and Fas ligand (FasL) can be used as novel biomarkers of acute pancreaticoduodenal allograft dysfunc...

journal_title：Digestive diseases and sciences

authors： Dong GH,Li XF,Li JZ,Zhang ZD,Hu WM,Luo YH,Li ZD,Tian BL,He MX,Zhu XW

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Computed tomography (CT) and magnetic resonance (MR) enterography are now widely used to diagnose and monitor Crohn's disease. AIM:We sought to assess the use of enterography for management of inflammatory bowel disease (IBD) in our medical center. METHODS:We performed a retrospective review of all patient...

journal_title：Digestive diseases and sciences

authors： Patel NS,Pola S,Muralimohan R,Zou GY,Santillan C,Patel D,Levesque BG,Sandborn WJ

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Treatment with tumor necrosis factor-α (TNF-α) inhibitors in patients with Crohn's disease (CD) is associated with potentially serious infections, including tuberculosis (TB) and hepatitis B virus (HBV). We assessed the cost-effectiveness of extensive TB screening and HBV screening prior to initiati...

journal_title：Digestive diseases and sciences

authors： van der Have M,Oldenburg B,Fidder HH,Belderbos TD,Siersema PD,van Oijen MG

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:We conducted a systematic review and meta-analysis of meat intake and esophageal cancer risk, with subgroup analyses based on meat type and histological type of cancer. AIMS:The purpose of this study was to investigate the association between meat intake and risk of esophageal cancer. METHODS:We searched M...

journal_title：Digestive diseases and sciences

authors： Zhu HC,Yang X,Xu LP,Zhao LJ,Tao GZ,Zhang C,Qin Q,Cai J,Ma JX,Mao WD,Zhang XZ,Cheng HY,Sun XC

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:Few studies compare gastroesophageal reflux (GER) parameters of cystic fibrosis (CF) children and symptomatic non-CF children. We aimed to compare the impedance-pH (IMP-pH) parameters for these two groups and to test the hypothesis that prolonged acid exposure in CF patients is due to delayed chemical cleara...

journal_title：Digestive diseases and sciences

authors： Woodley FW,Machado RS,Hayes D Jr,Di Lorenzo C,Kaul A,Skaggs B,McCoy K,Patel A,Mousa H

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Subjects with fatty liver disease (FLD) can show increased hepatic 2-deoxy-2-((18)F)fluoro-D-glucose (FDG) uptake, but the role of hepatic inflammation has not been explored. AIMS:We investigated whether hepatic inflammatory response, as implicated by elevated serum markers, is associated with increased liv...

journal_title：Digestive diseases and sciences

authors： Hong SP,Noh TS,Moon SH,Cho YS,Lee EJ,Choi JY,Kim BT,Lee KH

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Concerns over the hypothetical adverse effects of water absorption and the disturbance of serum sodium and potassium levels prompted a quality assurance evaluation of water exchange (WE) colonoscopy. AIM:The purpose of this study was to evaluate the balance of water infused and suctioned in WE colonoscopy, ...

journal_title：Digestive diseases and sciences

authors： Leung JW,Siao-Salera R,Abramyan O,Mann SK,Ward G,Yen A,Gutierrez R,Leung FW

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Percutaneous endoscopic gastrostomy (PEG) is a commonly performed procedure for patients with severe dysphagia leading to malnutrition. Improved knowledge of risk factors for PEG-related complications might decrease patient discomfort and healthcare costs. AIM:The aim of the present study was to investigate...

journal_title：Digestive diseases and sciences

authors： Lee SP,Lee KN,Lee OY,Lee HL,Jun DW,Yoon BC,Choi HS,Kim SH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The dose recommendation for entecavir (ETV) is 0.5 mg daily for treatment-naïve chronic hepatitis B (CHB) patients and 1.0 mg daily for lamivudine-refractory patients; however, few data are available for the efficacy of a 1.0-mg daily dose in treatment-naïve CHB patients. Our goal is to examine the ...

journal_title：Digestive diseases and sciences

authors： Ha NB,Ha NB,Chaung KT,Trinh HN,Nguyen HA,Nguyen KK,Nguyen MH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Traditional endoscopic management of benign biliary strictures (BBS) consists of placement of one or more plastic stents. Emerging data support the use of covered self-expandable metal stents (CSEMS). We sought to assess outcome of endoscopic temporary placement of CSEMS in patients with BBS. METHO...

journal_title：Digestive diseases and sciences

authors： Irani S,Baron TH,Akbar A,Lin OS,Gluck M,Gan I,Ross AS,Petersen BT,Topazian M,Kozarek RA

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Although a genetic component has been identified as a risk factor for developing inflammatory bowel disease, there is evidence that dietary factors also play a role in the development of this disease. AIMS:The aim of this study was to determine the effects of feeding a red meat diet with and without resista...

journal_title：Digestive diseases and sciences

authors： Le Leu RK,Young GP,Hu Y,Winter J,Conlon MA

更新日期：2013-12-01 00:00:00

abstract：AIM:To evaluate the use of health care resources and the associated costs of complex perianal Crohn's disease (CD) from the National Health System perspective. METHODS:We conducted a multicenter, retrospective, observational study in which gastroenterologists from 11 hospitals in the Community of Madrid took part. Dat...

journal_title：Digestive diseases and sciences

authors： Chaparro M,Zanotti C,Burgueño P,Vera I,Bermejo F,Marín-Jiménez I,Yela C,López P,Martín MD,Taxonera C,Botella B,Pajares R,Ponferrada A,Calvo M,Algaba A,Pérez L,Casis B,Maté J,Orofino J,Lara N,García-Losa M,Badia

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIM:Familial Mediterranean fever (FMF), the most frequent periodic fever syndrome, is an autosomal recessive inherited disease that predominantly affects eastern Mediterranean populations. Fetuin-A is a well known negative acute-phase protein. Studies of this glycoprotein as a marker of inflammation in FMF a...

journal_title：Digestive diseases and sciences

authors： Oncu K,Yazgan Y,Tanoglu A,Kaplan M,Ermis F,Ipcioglu OM,Kara M,Kucuk I,Ozari HO

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The underlying mechanisms of nonalcoholic steatohepatitis (NASH) are poorly understood, and little is known about hepatocellular apoptosis in NASH. Cyclooxygenase (COX)-2, the key enzyme in eicosanoid metabolism, is highly expressed in NASH. COX-2 can also regulate the release of mediators of inf...

journal_title：Digestive diseases and sciences

authors： Cheng Q,Li N,Chen M,Zheng J,Qian Z,Wang X,Huang C,Xu S,Shi G

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Pyoderma gangrenosum is a serious cutaneous complication seen in approximately 1 % of patients with inflammatory bowel disease (IBD). Oral corticosteroids are the mainstay treatment, although the evidence supporting their use is weak. AIMS:The purpose of this study was to investigate the characteristics of ...

journal_title：Digestive diseases and sciences

authors： Argüelles-Arias F,Castro-Laria L,Lobatón T,Aguas-Peris M,Rojas-Feria M,Barreiro-de Acosta M,Soto-Escribano P,Calvo-Moya M,Ginard-Vicens D,Chaparro-Sánchez M,Hernández-Durán M,Castro-Senosiain B,Fernández-Villaverde A,García-Sán

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND/AIM:We have previously reported that bee venom (BV) has a protective role against acute pancreatitis (AP). However, the effects of apamin, the major compound of BV, on AP have not been determined. The aim of this study was to evaluate the effects of apamin on cerulein-induced AP. METHODS:AP was induced via ...

journal_title：Digestive diseases and sciences

authors： Bae GS,Heo KH,Park KC,Choi SB,Jo IJ,Seo SH,Kim DG,Shin JY,Kang DG,Lee HS,Song HJ,Shin BC,Park SJ

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Fecal Occult Blood Test (FOBT) is an accepted screening test for colorectal cancer (CRC). It has been shown to decrease mortality by up to 30%. The outcome of screening failures has not been adequately studied. AIMS:The purpose of this study was to assess the outcome of patients who were diagnosed with CRC ...

journal_title：Digestive diseases and sciences

authors： Half EE,Mlynarsky L,Naftali T,Benjaminov F,Konikoff FM

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Enhanced cell expression of MAdCAM-1 is critical in tissue recruitment of lymphocytes in response to stimuli expressing the α4β7 integrin. MAdCAM-1 is well characterized in gut mucosa with emerging evidence of hepatic expression. AIMS:(i) Compare quantitative/semi-quantitatively MAdCAM-1 expression in relat...

journal_title：Digestive diseases and sciences

authors： Ala A,Brown D,Khan K,Standish R,Odin JA,Fiel MI,Schiano TD,Hillan KJ,Rahman SA,Hodgson HJ,Dhillon AP

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Major modification of the 7th tumor-node-metastasis (TNM) staging system for hepatocellular carcinoma (HCC) was divided into 6th stage IIIA to 7th IIIA (multiple tumors, any>5 cm) and IIIB (tumors involving a major vessel). This study aimed to validate 6th and 7th TNM systems in prognostic prediction, then a...

journal_title：Digestive diseases and sciences

authors： Kee KM,Wang JH,Lin CY,Wang CC,Cheng YF,Lu SN

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Notch signaling is required for the maintenance of intestinal epithelial proliferation. Dysfunction of this signaling pathway is associated with the loss of proliferated crypt epithelial cells. AIM:The aim of this study was to investigate the role of Notch signaling in small bowel resection (SBR)-associated...

journal_title：Digestive diseases and sciences

authors： Chen G,Sun L,Yu M,Meng D,Wang W,Yang Y,Yang H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Gut dysmotility is closely associated with proinflammatory cytokines both in irritable bowel syndrome and inflammatory bowel disease. There is a dose-response relationship between depression and these inflammatory cytokines. AIMS:In the present study, we aimed to investigate the effect of Interleukin-6 (IL-...

journal_title：Digestive diseases and sciences

authors： Zhang L,Hu L,Chen M,Yu B

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Optical frequency domain imaging (OFDI) is a second-generation form of optical coherence tomography (OCT) providing comprehensive cross-sectional views of the distal esophagus at a resolution of ~7 μm. AIM:Using validated OCT criteria for squamous mucosa, gastric cardia mucosa, and Barrett's esophagus (BE),...

journal_title：Digestive diseases and sciences

authors： Sauk J,Coron E,Kava L,Suter M,Gora M,Gallagher K,Rosenberg M,Ananthakrishnan A,Nishioka N,Lauwers G,Woods K,Brugge W,Forcione D,Bouma BE,Tearney G

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) is the number one cause of liver disease in the United States. The prevalence rates in African Americans (AA), while significantly lower than other ethnic groups with similar known risk factors, have been quoted as high as 24 %. We aim to determine if the pre...

journal_title：Digestive diseases and sciences

authors： Foster T,Anania FA,Li D,Katz R,Budoff M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The effect of the cystic fibrosis transmembrane conductance regulator protein (CFTR) defect in pancreatic insufficient (PI) patients with cystic fibrosis (CF) on the gastrointestinal pH profile is poorly defined. Adequate and efficient neutralization of the gastric acidity in the duodenum is importa...

journal_title：Digestive diseases and sciences

authors： Gelfond D,Ma C,Semler J,Borowitz D

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Our previous study has shown that MYO5B is downregulated in gastric cancer. However, the mechanism by which the expression of MYO5B was inhibited remains unknown. METHODS:Inspection of the human MYO5B locus uncovered a large and dense CpG island within the 5' region of this gene. Methylation-specific PCR (M...

journal_title：Digestive diseases and sciences

authors： Dong W,Wang L,Shen R

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess safety, efficacy, and clinical outcomes following transcatheter arterial embolization (TAE) of acute gastrointestinal (GI) bleeding. MATERIALS AND METHODS:Ninety-five patients (male:female ratio = 53:42, mean age 62 years) that underwent 95 TAEs for GI hemorrhage between...

journal_title：Digestive diseases and sciences

authors： Yap FY,Omene BO,Patel MN,Yohannan T,Minocha J,Knuttinen MG,Owens CA,Bui JT,Gaba RC

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Intrasphincteric injection of botulinum toxin (BTX) and removable self-expanding metal stents (SEMS) have both been used for the treatment of achalasia. AIM:To compare the effectiveness and long-term outcome of SEMS placement and BTX injection in patients with achalasia. METHODS:A total of 110 patients wit...

journal_title：Digestive diseases and sciences

authors： Cai XB,Dai YM,Wan XJ,Zeng Y,Liu F,Wang D,Zhou H

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) is a safe and effective way to sample lesions in the gastrointestinal tract. Rapid on-site specimen evaluation (ROSE) improves the accuracy of EUS-FNA. While data suggests that EUS with fine-needle biopsy (EUS-FNB) is effective, it remains unclear...

journal_title：Digestive diseases and sciences

authors： Krishnan K,Dalal S,Nayar R,Keswani RN,Keefer L,Komanduri S

更新日期：2013-07-01 00:00:00

abstract：:The destruction of the integrity of the gastric epithelial barrier underlies the pathology of many gastric diseases, including gastric tumors. The Helicobacter pylori virulence factor CagA is one of the main destroyers of the gastric epithelial barrier. There are differences among CagA proteins that originate from dif...

journal_title：Digestive diseases and sciences

authors： Wu J,Xu S,Zhu Y

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Estradiol-17β-D-glucuronide (E17G) induces cholestasis in vivo, endocytic internalization of the canalicular transporters multidrug resistance-associated protein 2 (Abcc2) and bile salt export pump (Abcb11) being a key pathomechanism. Cyclic AMP (cAMP) prevents cholestasis by targeting these transporters bac...

journal_title：Digestive diseases and sciences

authors： Zucchetti AE,Barosso IR,Boaglio AC,Luquita MG,Roma MG,Crocenzi FA,Sánchez Pozzi EJ

更新日期：2013-06-01 00:00:00